result - 7 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP045110.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	arylpolyene,NRPS,hserlactone	146,276	229,467	lagriene	Polyketide	4%
Region 1.2	arylpolyene	881,474	922,703	berninamycin K/berninamycin J/berninamycin A/berninamycin B	RiPP	22%
Region 1.3	betalactone	1,705,371	1,734,452	mycosubtilin	NRP+Polyketide	20%
Region 1.4	NI-siderophore	1,985,904	2,022,347	baumannoferrin A/baumannoferrin B	Other	100%
Region 1.5	redox-cofactor	2,116,839	2,139,029	lankacidin C	NRP+Polyketide	13%
Region 1.6	NRP-metallophore	2,859,957	2,913,160	acinetobactin	NRP	100%
Region 1.7	NAPAA	3,122,247	3,156,245

No secondary metabolite regions were found in these records:: NZ_CP045108.1; NZ_CP045109.1

Compact view

NZ_CP045110.1 - Region 1 - NRPS,arylpolyene,hserlactone

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Location: 146,276 - 229,467 nt. (total: 83,192 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)
NRPS: cds(Condensation and (AMP-binding or A-OX))
hserlactone: Autoind_synth

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

NRPS/PKS domains

KnownClusterBlast

SubClusterBlast

NRPS/PKS modules

Pfam domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

Similar subclusters

No matches found.

Module view

Legend

Detailed Pfam domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 146275 - 229467:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 185507 - 229467:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg1_187

AMP-binding (38..443): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: AYYASAHMVK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

ctg1_195

CAL_domain (162..486): pk

minowa: NH2

Prediction, score:

NH2: 119.3
Acetyl-CoA: 60.3
fatty_acid: 21.4
shikimic_acid: 0.0
AHBA: 0.0

ctg1_198

Search NORINE for peptide: strict or relaxed

AMP-binding (486..872): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGVVWK
Nearest Stachelhaus code(s):: Gly DILQLGVVWK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

NZ_CP045110.1 - Region 2 - arylpolyene

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Location: 881,474 - 922,703 nt. (total: 41,230 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

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core biosynthetic genes

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transport-related genes

regulatory genes

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Gene details

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Gene overview

NRPS/PKS domains

KnownClusterBlast

SubClusterBlast

Pfam domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

Similar subclusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

NRPS/PKS substrates

NRPS/PKS substrate predictions

NZ_CP045110.1 - Region 3 - betalactone

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Location: 1,705,371 - 1,734,452 nt. (total: 29,082 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

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core biosynthetic genes

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KnownClusterBlast

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Pfam domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

Similar subclusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

NZ_CP045110.1 - Region 4 - NI-siderophore

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Location: 1,985,904 - 2,022,347 nt. (total: 36,444 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

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Gene details

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Gene overview

KnownClusterBlast

SubClusterBlast

Pfam domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

Similar subclusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

NZ_CP045110.1 - Region 5 - redox-cofactor

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Location: 2,116,839 - 2,139,029 nt. (total: 22,191 nt) Show pHMM detection rules used

redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

Gene overview

KnownClusterBlast

SubClusterBlast

Pfam domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

Similar subclusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

NZ_CP045110.1 - Region 6 - NRP-metallophore

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Location: 2,859,957 - 2,913,160 nt. (total: 53,204 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

NRPS/PKS domains

KnownClusterBlast

SubClusterBlast

Pfam domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

Similar subclusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

NRPS/PKS substrates

NRPS/PKS substrate predictions

ctg1_2747

Search NORINE for peptide: strict or relaxed

AMP-binding (37..442): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: MLPSQGVVNK
Nearest Stachelhaus code(s):: diOH-Bz PLPSQGVVNK (94% 8Å match)
Stachelhaus code match:: 90% (moderate)

ctg1_2757

Search NORINE for peptide: strict or relaxed

AMP-binding (31..417): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DMFSAGLIWK
Nearest Stachelhaus code(s):: Thr DMFVAGLIWK (91% 8Å match)
Stachelhaus code match:: 90% (moderate)

NZ_CP045110.1 - Region 7 - NAPAA

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Location: 3,122,247 - 3,156,245 nt. (total: 33,999 nt) Show pHMM detection rules used

NAPAA: (AMP-binding and TIGR02353)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

NRPS/PKS domains

KnownClusterBlast

SubClusterBlast

NRPS/PKS modules

Pfam domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

No matches found.

Similar subclusters

No matches found.

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 10, location 3122246 - 3156245:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Lys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg1_2965

Search NORINE for peptide: strict or relaxed

AMP-binding (29..418): Lys

nrpys: Lys

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DMEHNGTVSK
Nearest Stachelhaus code(s):: Lys DAEDNGTVSK (56% 8Å match)
Stachelhaus code match:: 80% (moderate)