基本信息

Performing prediction of carbohydrate-active enzymes and functional annotation using the emapper software

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The Carbohydrate-Active Enzymes Database (CAZy) is a knowledgebase specializing in enzymes that construct or hydrolyze glycosidic bonds in complex carbohydrates. It classifies these enzymes into glycoside hydrolase (GH), glycosyltransferase (GT), polysaccharide lyase (PL), carbohydrate esterase (CE), and auxiliary activities (AA) families based on conserved catalytic domain architectures revealed by amino acid sequence similarity. The database integrates multidimensional data including phylogenetic origin, genomic context, three-dimensional structures, and associated EC numbers for each characterized enzyme.

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eggNOG-mapper v2 is a tool for functional annotation of large sets of sequences based on fast orthology assignments using precomputed eggNOG v5.0 clusters and phylogenies. 

补充信息

Related links:

http://www.cazy.org/

http://eggnog-mapper.embl.de/

参考文献

Drula E, Garron ML, Dogan S, Lombard V, Henrissat B, Terrapon N. The carbohydrate-active enzyme database: functions and literature. Nucleic Acids Res. 2022;50(D1):D571-D577. doi:10.1093/nar/gkab1045

Cantalapiedra CP, Hernández-Plaza A, Letunic I, Bork P, Huerta-Cepas J. eggNOG-mapper v2: Functional Annotation, Orthology Assignments, and Domain Prediction at the Metagenomic Scale. Mol Biol Evol. 2021;38(12):5825-5829. doi:10.1093/molbev/msab293