A KEGG circle plot is a visualization tool used to display the results of KEGG enrichment analysis. It typically consists of multiple concentric circles (tracks), with each circle layer representing different information.

Input

The first column is "gene", the second column is "logFC", and they are separated by a tab character (\t).

Output

Chart Description

1. KEGG Chord Diagram

Structure:

• The KEGG chord diagram is based on a circular layout.

• One side of the outer ring represents significantly enriched KEGG pathways (Terms), while the opposite side displays the input genes.

Connections (Chords):

• Each chord connects a KEGG pathway to a gene, indicating that the gene is annotated/enriched in that pathway.

• These connections visually reveal which genes participate in which pathways and whether different pathways share common genes.

Colors & Labels:

• Different KEGG pathways and genes are distinguished by unique colors.

2. KEGG Cluster Diagram

Structure:

• The cluster diagram groups KEGG pathways based on functional similarity or gene overlap, illustrating relationships and similarities between pathways.

Purpose:

• Helps identify functionally related pathways or those with significant gene overlap.

• Aids in understanding the overall structure of biological processes.